The olive oil tree (Olea europaea L.) contains hydrophilic and lipophilic bioactive compounds, which include flavones, phenolic acids, phenolic alcohols, secoiridoids, and hydroxycinnamic acid derivatives. These bioactive compounds have anti-inflammatory, antimicrobial, and antioxidant properties, and therefore, olive-derived plant bioactive compounds may reduce chronic inflammation and intestinal integrity in pigs. Therefore, olive-derived plant bioactive compounds, such as Olextra 1200, may improve health and prevent disease by inhibiting B cell activation and cytokine expression. However, there is a lack of data demonstrating effects of olive extracts on reproductive performance of sows and their offspring. Therefore, the objective of this experiment was to test the hypothesis that dietary supplementation of Olextra 1200 increases reproductive performance as well as the immune status of sows.