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Effects of 25-hydroxycholecalciferol (25-OH-D3) and 1-hydroxycholecalciferol (1-OH-D3) on serum bone biomarkers and calcium and phosphorus balance and concentrations of energy in diets without or with microbial phytase fed to sows in late gestation

Lee, Su A , Leidy J. Torres-Mendoza, and Hans H. Stein1. 2022. Effects of 25-hydroxycholecalciferol (25-OH-D3) and 1-hydroxycholecalciferol (1-OH-D3) on serum bone biomarkers and calcium and phosphorus balance and concentrations of energy in diets without or with microbial phytase fed to sows in late gestation. Journal of Animal Science, 2022, 100, 1–8. doi.org/10.1093/jas/skac299.

Effects of 25-hydroxycholecalciferol (25-OH-D3)and 1-alpha-hydroxycholecalciferol (1-α-OH-D3) on serum bone biomarkers and calcium and phosphorus balance and concentrations on energy in diets without or with microbial phytase fed to sows in late gestation

Absorption of Ca and P by active transport in the small intestine is regulated by calcitriol, which is the active form of vitamin D (1,25-dihydroxycholecalciferol) and the hormones calcitonin and PTH. One-alpha-hydroxycholecalciferol (1-α-OH-D3) and 25-hydroxycholecalciferol (25-OH-D3) are vitamin D metabolites that may be added to diets for pigs. Because 1-α-OH-D3 is already hydroxylated at the 1-position, only the first hydroxylation in the liver at the 25-position is needed to convert the metabolite to calcitriol. Likewise, because the 25-OH-D3 is already hydroxylated at the 25-position, only the second hydroxylation in the kidney at the 1-position is needed if this metabolite is used. It is possible that supplementation of diets with 25-OH-D3 or 1-α-OH-D3 increases absorption and retention of Ca and P by increasing the conversion efficiency to calcitriol compared with the conversion of cholecalciferol to calcitriol. It is possible that the effects on Ca and P balance differ between 25-OH-D3 and 1-α-OH-D, but research to test this hypothesis has not been reported.

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