nitrogen balance

Effect of soy isoflavones and nitrogen-source on nitrogen balance in low-protein diets fed to growing pigs

Soybean meal (SBM) is the primary source of amino acids (AA) and energy in diets for swine throughout the world. However, less SBM is often used in diets to decrease nitrogen (N) excretion and environmental pollution. Nonetheless, it is demonstrated that lowering dietary protein does not consistently deliver the same performance of pigs as of pigs fed high protein diets, even though all indispensable AA meet the requirements of pigs. It is possible that soybean-derived bioactive compounds (i.e., soy isoflavones and saponins) in SBM act as immunomodulators, which improve the performance of pigs. It is also possible that low-protein diets contain N below the requirements for pigs to maximize growth. However, no data are available to prove this hypothesis. Therefore, the objective of this experiment was to test the hypothesis that N balance of pigs is not affected by reducing dietary protein if soy isoflavones or N source are supplemented in diets.

Keywords: 
nitrogen balance, Retention, Soybean meal
Authors: 
Ibagon, Stein, Lee
Publication Type: 
Research Reports

Effects of dietary isoleucine and valine supplementation to excess or low leucine diets on nitrogen balance and metabolism of branched-chained amino acids in growing pigs

Kwon, Woong B., Jose A. Soto, Hans H. Stein. 2020. Effects of dietary isoleucine and valine supplementation to excess or low leucine diets on nitrogen balance and metabolism of branched-chained amino acids in growing pigs. J. Anim. Sci. 98(Suppl. 3): 33. doi.org/10.1093/jas/skaa054.059. (Abstr.). Link to abstract.

Keywords: 
branched-chain amino acids, nitrogen balance, Pigs
Authors: 
Kwon, Soto, Stein
Publication Type: 
Abstracts

Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine

Kwon, Woong B., Jose A. Soto, and Hans H. Stein. 2020. Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine. Journal of Animal Science, 2020, Vol. 98, No. 11, 1–10. doi:10.1093/jas/skaa346.

Keywords: 
branched-chain amino acids, isoleucine, leucine, nitrogen balance, Pigs, valine
Authors: 
Kwon, Soto, Stein
Publication Type: 
Peer-reviewed journal articles

Effects of dietary isoleucine and valine supplementation to excess or low leucine diets on nitrogen balance and metabolism of branched-chain amino acids in growing pigs

Leucine is a key regulator that stimulates catabolism of branched-chain AA (BCAA; i.e., Leu, Ile, and Val) in skeletal muscle and liver. If diets fed to pigs contain excess Leu, catabolism of all 3 BCAA may increase because of the stimulating effect of the Leu metabolite, α-keto isocaproate, on the branched-chain α-keto acid dehydrogenase enzyme complex, which is responsible for degradation of the 3 branched-chain α-keto acids that originate from metabolism of the 3 BCAA. Serum Ile and Val concentrations were reduced by excess dietary Leu in growing pigs, and high dietary Leu reduces feed intake and growth performance in pigs, which may be a result of the imbalanced supply of BCAA that result from increased metabolism of Val and Ile. Recent data confirmed that excess dietary Leu reduced growth performance and tended to reduce protein synthesis, which is likely a result of reduced availability of Val and Ile.

Keywords: 
branched-chain amino acids, leucine, nitrogen balance, Pigs
Authors: 
Kwon, Stein
Publication Type: 
Research Reports

Effects of dietary leucine concentration on branched-chain amino acid metabolism in growing pigs

Kwon Woong B., Kevin J. Touchette, Aude Simongiovanni, Kostas Syriopoulos, Anna Wessels, Hans H. Stein. 2019. Effects of dietary leucine concentration on branched-chain amino acid metabolism in growing pigs. Journal of Animal Science, Volume 97, Issue Supplement_2, July 2019, Pages 65–66. (Abstr.). Link to abstract.

Keywords: 
branched-chain amino acids, Growth performance, nitrogen balance
Authors: 
Kwon, Touchette, Simongiovanni, Syriopoulos, Wessels, Stein
Publication Type: 
Abstracts