Tryptophan

Tryptophan can partially overcome negative effects of leucine in pig diets

Kwon, W. B., and H. H. Stein. 2020. Tryptophan can partially overcome negative effects of leucine in pig diets. National Hog Farmer, Online edition. Jan.

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Excess dietary leucine in diets for growing pigs reduces growth performance, biological value of protein, protein retention, and serotonin synthesis

Kwon, Woong B., Kevin J. Touchette, Aude Simongiovanni, Kostas Syriopoulos, Anna Wessels, and Hans H. Stein. 2019. Excess dietary leucine in diets for growing pigs reduces growth performance, biological value of protein, protein retention, and serotonin synthesis. Journal of Animal Science, 2019, 4282–4292. Link to full text.

Effects of dietary leucine and tryptophan supplementation on serotonin metabolism and growth performance of growing pigs

Tryptophan is an indispensable AA that is often limiting for growth in pigs fed corn-soybean meal-based diets. Tryptophan may act as a regulator of feed intake by enhancing serotonin signaling in the brain, because Trp is a precursor for serotonin. High Trp intake increases feed intake, and this is partly attributed to increased serotonin synthesis. Availability of dietary Trp in the brain is considered the rate-limiting step in hypothalamic serotonin synthesis. However, to be transported into the brain, Trp competes with other large neutral AA such as Val, Leu, Ile, Tyr, and Phe for a common transporter (L-type AA transporter 1) to cross the blood-brain barrier.

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Effects of dietary leucine and tryptophan supplementations on serotonin metabolism and growth performance of growing pigs.

Kwon, W. B., K. J. Touchette, A. Simongiovanni, K. Syriopoulos, A. Wessels, and H. H. Stein. 2019. Effects of dietary leucine and tryptophan supplementations on serotonin metabolism and growth performance of growing pigs. In: 6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition, Belo Horizonte, Minas Gerais, Brazil, Sep. 9-12, 2019. Pages 303-304.

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Estimation of the ideal tryptophan:lysine ration in 10- to 20-kg pigs

Petersen, G. I. and H. H. Stein. 2012. Estimation of the ideal tryptophan:lysine ration in 10- to 20-kg pigs. J. Anim. Sci. 90(E-Suppl. 2):60 (Abstr.) Link to abstract (.pdf)

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Determination of Lys and Trp requirements in 10 to 20 kg pigs

Petersen, G. I. and H. H. Stein. 2011. Determination of Lys and Trp requirements in 10 to 20 kg pigs. J. Anim. Sci. 89(E-Suppl. 2):100 (Abstr.) Link to abstract (.pdf)

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