Kwon

Effects of dietary leucine concentration on branched-chain amino acid metabolism in growing pigs

Leucine, Val, and Ile are categorized as the branched-chain AA (BCAA) because of the structural similarity of their side chains. All 3 BCAA share the enzymes that are involved in the first 2 steps of their catabolic pathway. The first step is a transamination step catalyzed by BCAA transaminase (BCAT) and producing branched-chain α-keto acids (BCKA). The second step is an irreversible degradation step catalyzed by branched-chain α-keto acid dehydrogenase (BCKDH). In the second step, Leu has been considered a key regulator as its BCKA metabolite (α-keto isocaproate) stimulates activation of the BCKDH complex in the liver. When excess Leu in diets is offered to pigs, degradation of all 3 BCAA may increase because of increased activity of BCAT and BCKDH. Leucine and Trp are both categorized as large neutral AA, and they share a common uptake pathway across the blood-brain barrier. Therefore, it is possible that excessive Leu may result in reduced Trp uptake into the brain due to competition for transporters, resulting in reduced serotonin synthesis.

 

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Non-antibiotic feed additives in diets for pigs: A review

Yanhong Liu, Charmaine D. Espinosa, Jerubella J. Abelilla, Gloria A. Casas, L. Vanessa Lagos, Su A. Lee, Woong B. Kwon, John K. Mathai, Diego M.D.L. Navarro, Neil W. Jaworski, Hans H. Stein. 2018. Non-antibiotic feed additives in diets for pigs: A review. Anim. Nutr. 4:113-125. Link to full text (.pdf)

Amino acid digestibility of a modified corn byproduct (Gold Pro) with and with a multi-enzyme supplement (CORE) when fed to weanling pigs

Soltwedel, K. T., F. B. Sandberg, W. B. Kwon, H. H. Stein, S. J. England, M. R. Bible, T. M. Fakler, and J. Y. Jacela. 2018. Amino acid digestibility of a modified corn byproduct (Gold Pro) with and with a multi-enzyme supplement (CORE) when fed to weanling pigs. J. Anim. Sci. 96(Suppl. 2):150 (Abstr.) Link to abstract (.pdf)

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Non-antibiotic feed additives in diets for pigs

Liu, Y., D. Espinosa, J. J. Abelilla, G. A. Casas, L. V. Lagos, S. A. Lee, W. B. Kwon, J. K. Mathai, D. M.D. L. Navarro, N. W. Jaworski, and H. H. Stein. 2016. Non-antibiotic feed additives in diets for pigs. Pages 263-281 in Proceedings of the 2016 Chinese Swine Industry Symposium, Shanghai, China, October 20-21, 2016. Link to full text (.pdf)

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