branched-chain amino acids

Effects of dietary isoleucine and valine supplementation to excess or low leucine diets on nitrogen balance and metabolism of branched-chained amino acids in growing pigs

Kwon, Woong B., Jose A. Soto, Hans H. Stein. 2020. Effects of dietary isoleucine and valine supplementation to excess or low leucine diets on nitrogen balance and metabolism of branched-chained amino acids in growing pigs. Journal of Animal Science, Volume 98, Issue Supplement_3, November 2020, Page 33. (Abstr.). Link to abstract.

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Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine

Kwon, Woong B., Jose A. Soto, and Hans H. Stein. 2020. Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine. Journal of Animal Science, 2020, Vol. 98, No. 11, 1–10. doi:10.1093/jas/skaa346.

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Effects of dietary isoleucine and valine supplementation to excess or low leucine diets on nitrogen balance and metabolism of branched-chain amino acids in growing pigs

Leucine is a key regulator that stimulates catabolism of branched-chain AA (BCAA; i.e., Leu, Ile, and Val) in skeletal muscle and liver. If diets fed to pigs contain excess Leu, catabolism of all 3 BCAA may increase because of the stimulating effect of the Leu metabolite, α-keto isocaproate, on the branched-chain α-keto acid dehydrogenase enzyme complex, which is responsible for degradation of the 3 branched-chain α-keto acids that originate from metabolism of the 3 BCAA. Serum Ile and Val concentrations were reduced by excess dietary Leu in growing pigs, and high dietary Leu reduces feed intake and growth performance in pigs, which may be a result of the imbalanced supply of BCAA that result from increased metabolism of Val and Ile. Recent data confirmed that excess dietary Leu reduced growth performance and tended to reduce protein synthesis, which is likely a result of reduced availability of Val and Ile.

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Excess dietary leucine in diets for growing pigs reduces growth performance, biological value of protein, protein retention, and serotonin synthesis

Kwon, Woong B., Kevin J. Touchette, Aude Simongiovanni, Kostas Syriopoulos, Anna Wessels, and Hans H. Stein. 2019. Excess dietary leucine in diets for growing pigs reduces growth performance, biological value of protein, protein retention, and serotonin synthesis. Journal of Animal Science, 2019, 4282–4292. Link to full text.

Effects of dietary leucine concentration on branched-chain amino acid metabolism in growing pigs

Kwon Woong B., Kevin J. Touchette, Aude Simongiovanni, Kostas Syriopoulos, Anna Wessels, Hans H. Stein. 2019. Effects of dietary leucine concentration on branched-chain amino acid metabolism in growing pigs. Journal of Animal Science, Volume 97, Issue Supplement_2, July 2019, Pages 65–66. (Abstr.). Link to abstract.

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